My clinical focus is on cognitive neurology and neurodegenerative disease including frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis, progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy. I have a particular interest in young-onset dementia and the behavioral variant of frontotemporal dementia.
My research program focuses on the interface of clinical symptoms and underlying neuropathology in neurodegenerative disease. The purpose of this approach is to better identify clinically, pathologically and genetically homogeneous patient populations for inclusion into clinical trials to efficiently study emerging disease modifying treatments that target the pathogenic proteins specific for each neuropathological subtype of disease (e.g. FTLD-associated with tau or TDP-43 protein inclusions). Currently, the diagnostic standard is neuropathological examination at autopsy, which is a major obstacle for clinical trials in neurodegenerative disease. To address this problem our approach is to "work backwards" to study human brain tissue and measure neuropathology objectively using novel open-source digital image analysis tools; We use a "tissue-guided biomarker discovery” method to translate our findings with the ultimate goal to develop new laboratory and imaging tests to detect pathology in living patients.
Credentials
MDGender
MaleGraduation year
2006Years of experience
18Professional School
Drexel University Center City Hahnemann CampusResidency
Hahnemann University HospitalMonday:
8:00AM - 5:00PM
Tuesday:
8:00AM - 5:00PM
Wednesday:
8:00AM - 5:00PM
Thursday:
8:00AM - 5:00PM
Friday:
8:00AM - 5:00PM
Saturday:
Closed
Sunday:
Closed
David J. Irwin, MD generally accepts new patients.
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The top specialties of David J. Irwin, MD include Neurology
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The office is located at 3400 Civic Center Boulevard in Philadelphia, PA.
David J. Irwin, MD accepts various types of health insurance, but individual coverage may be variable. You should check with your health insurance whether the particular doctor is in network or not.
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